How to get here
There are two main options for international travel to Posadas.

Option 1: Via Brazil

This is the cheapest option from the United States, Europe and Latin America countries. The port of entry would be the city of Sao Paulo or Rio de Janeiro making connection to the city of Foz do Iguaçu (over 20 daily flights) at the border with Argentina, then to Posadas 300 km away.
You can take advantage to visit the Iguazu Falls, recently named one of the seven natural wonders of the world.
U.S. citizens needs a visa to enter Brazil.

Option 2 : Via Argentina

It is a slightly more expensive option but the trip is completely by air. The port of entry is the city of Buenos Aires connecting directly to Posadas with two daily flights. There is a change of airports in Buenos Aires. On arrival in Posadas, the transfer from the airport to the hotel is included in the hotel rate.
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All major airlines cover those destinations with a large number of options.